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. 2024 Apr 2;196(12):E410–E414. doi: 10.1503/cmaj.230490

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Figure 1: — History, physical examination, and investigations for the workup of acute hepatitis. *Typical causes of alanine transaminase (ALT) or aspartate transaminase (AST) elevation greater than 1000 U/L. †Results may be abnormal in patients with acute inflammation, potentially confounding diagnosis. Note: ALP = alkaline phosphatase; AMA = antimitochondrial antibody; ANA = antinuclear antibody; ASMA = anti–smooth muscle antibody; ATP = adenosine triphosphate; CBC = complete blood count; eGFR = estimated glomerular filtration rate; hCG = human chorionic gonadotropin; GGT = γ-glutamyltransferase; HELLP = hemolysis, elevated liver enzymes, and low platelets; Ig = immunoglobulin; INR = international normalized ratio; NAAT = nucleic acid amplification test.