Table 5. Biomarkers and lifestyle behaviours stratified by sex, tumour anatomic site, and age category.
| Characteristic | N | Sex | Anatomic site | Age category | Overall N = 255 a |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Female N = 110 a |
Male N = 145 a |
p-value b | Colon N = 158 a |
Rectum N = 97 a |
p-value b | < 50 N = 56 a |
≥ 50 N = 199 a |
p-value b | |||
| KRAS status | 92 | 0.600 | 0.700 | 0.700 | |||||||
| Mutated | 26 (62%) | 28 (56%) | 35 (60%) | 19 (56%) | 15 (56%) | 39 (60%) | 54 (59%) | ||||
| Wild type | 16 (38%) | 22 (44%) | 23 (40%) | 15 (44%) | 12 (44%) | 26 (40%) | 38 (41%) | ||||
| NRAS status | 60 | > 0.900 | > 0.900 | 0.700 | |||||||
| Mutated | 3 (10%) | 3 (10%) | 4 (10%) | 2 (10%) | 3 (14%) | 3 (7.7%) | 6 (10%) | ||||
| Wild type | 27 (90%) | 27 (90%) | 36 (90%) | 18 (90%) | 18 (86%) | 36 (92%) | 54 (90%) | ||||
| BRAF status | 60 | 0.200 | 0.500 | > 0.900 | |||||||
| Mutated | 3 (10%) | 0 (0%) | 3 (7.3%) | 0 (0%) | 1 (4.5%) | 2 (5.3%) | 3 (5.0%) | ||||
| Wild type | 27 (90%) | 30 (100%) | 38 (93%) | 19 (100%) | 21 (95%) | 36 (95%) | 57 (95%) | ||||
| CEA | 136 | 0.800 | 0.035* | 0.300 | |||||||
| ≤ 5 | 32 (56%) | 46 (58%) | 59 (63%) | 19 (44%) | 11 (48%) | 67 (59%) | 78 (57%) | ||||
| ≥ 5 | 25 (44%) | 33 (42%) | 34 (37%) | 24 (56%) | 12 (52%) | 46 (41%) | 58 (43%) | ||||
| CEA level | 136 | 0.900 | 0.045* | 0.700 | |||||||
| Mean ± SD | 76 ± 329 | 55 ± 151 | 65 ± 267 | 60 ± 177 | 10 ± 11 | 75 ± 264 | 64 ± 241 | ||||
| Range | 0, 2,296 | 0, 1,000 | 0, 2,296 | 0, 1,000 | 0, 37 | 0, 2,296 | 0, 2,296 | ||||
| CA 19-9 | 135 | 0.800 | 0.900 | 0.200 | |||||||
| ≤ 35 | 39 (70%) | 57 (72%) | 65 (71%) | 31 (72%) | 19 (83%) | 77 (69%) | 96 (71%) | ||||
| ≥ 35 | 17 (30%) | 22 (28%) | 27 (29%) | 12 (28%) | 4 (17%) | 35 (31%) | 39 (29%) | ||||
| CA 19-9 level | 135 | 0.300 | > 0.900 | 0.200 | |||||||
| Mean ± SD | 153 ± 337 | 96 ± 235 | 127 ± 288 | 106 ± 272 | 64 ± 207 | 131 ± 295 | 120 ± 282 | ||||
| Range | 1, 1,200 | 1, 1,000 | 1, 1,000 | 1, 1,200 | 1, 1,000 | 1, 1,200 | 1, 1,200 | ||||
| Smoking | 62 | 0 (0%) | 46 (79%) | 0.003* | 29 (74%) | 17 (74%) | > 0.900 | 4 (80%) | 42 (74%) | > 0.900 | 46 (74%) |
| Alcohol | 41 | 0 (0%) | 15 (38%) | 0.500 | 10 (43%) | 5 (28%) | 0.300 | 2 (67%) | 13 (34%) | 0.500 | 15 (37%) |
*
p-value significant at below 0.050 threshold;
a
n (%);
b
Wilcoxon rank sum test;
Fisher’s exact test; Pearson’s chi-squared test