Table 2.
Macrohemodynamic and perfusion variables before and after the hemodynamic interventions
| Pre-intervention | Post-intervention | p-value | |
|---|---|---|---|
| Fluid challenge | |||
| CRT (s) | 5 [3.5–7.6] | 4 [2.4–5.1] | 0.008 |
| MAP (mmHg) | 66 [62–79] | 72 [62–75] | 0.96 |
| SAP (mmHg) | 101 [88–112] | 102 [97–108] | 0.99 |
| DAP (mmHg) | 56 [48–64] | 52 [45–60] | 0.17 |
| Pulse Pressure (mmHg) | 50 [39–56] | 50 [37–55] | 0.66 |
| HR (bpm) | 103 ± 24 | 104 ± 25 | 0.72 |
| NE Dose (mcg/kg/min) | 0.31 ± 0.17 | 0.35 ± 0.24 | 0.26 |
| CVP (mmHg) | 7.6 ± 4.4 | 5.9 ± 4.5 | 0.04 |
| CO (L/min) | 5.7 ± 1.7 | 6.3 ± 2.0 | 0.03 |
| SV (ml) | 56 ± 10 | 59 ± 7 | 0.2 |
| Vasopressor test | |||
| CRT (s) | 4.0 [3.3–5.6] | 3 [2.6 -5] | 0.03 |
| MAP (mmHg) | 67 [64–70] | 84 [82–87] | 0.0001 |
| SAP (mmHg) | 106 [96–118] | 132 [120–142] | 0.0001 |
| DAP (mmHg) | 47 [45–54] | 57 [53–60] | 0.0001 |
| Pulse Pressure (mmHg) | 55 [42–67] | 69 [62–87] | 0.002 |
| HR (bpm) | 88 ± 15 | 86 ± 18 | 0.17 |
| NE Dose (mcg/kg/min) | 0.18 ± 0.13 | 0.28 ± 0.19 | 0.001 |
| CVP (mmHg) | 9.2 ± 5 | 8.8 ± 4.7 | 0.9 |
| CO (L/min) | 4.7 ± 1.4 | 5.0 ± 1.7 | 0.15 |
| SV (ml) | 55 ± 17 | 59 ± 18 | 0.03 |
CRT: capillary refill time; MAP: mean arterial pressure; SAP: systolic arterial pressure; DAP: diastolic arterial pressure; HR: heart rate; NE: norepinephrine; CVP: central venous pressure; CO: cardiac output; SV: stroke volume. Data is presented as mean ± SD or median [interquartile range]. Paired t-test or Wilcoxon sum-rank test used accordingly