Table 1.

Mendelian randomization analysis of effects of genetically predicted PTSD on investigated phenotypes.

		Inverse variance weighted			IVW Het.	Weighted median
Phenotype	N SNPs	Beta	SE	pa	Q p	Beta	SE	pa
Connective tissues
Systemic lupus erythematosus	62	0.185	0.126	0.140	0.07	0.092	0.162	0.572
Systemic sclerosis	58	0.098	0.120	0.415	0.06	0.096	0.159	0.547
Digestive system
Celiac	57	−0.141	0.055	0.011	0.03	−0.136	0.070	0.051
Crohn’s	61	0.005	0.126	0.968	5.0E−08	0.066	0.128	0.605
Primary biliary cholangitis	55	0.248	0.148	0.093	0.02	0.243	0.182	0.181
Ulcerative colitis	62	−0.129	0.099	0.194	8.5E−04	−0.117	0.113	0.300
Endocrine
Addison’s	62	0.295	0.183	0.107	0.25	0.495	0.255	0.052
Autoimmune thyroid disease	62	0.150	0.038	8.7E−05	0.02	0.120	0.049	0.015
Type 1 diabetes	62	0.046	0.065	0.483	0.01	0.100	0.081	0.216
Hematological
Pernicious anemia	62	0.307	0.115	0.008	0.57	0.299	0.162	0.065
Inflammatory arthritis
Rheumatoid arthritis	62	0.018	0.081	0.824	1.0E−07	0.120	0.083	0.147
Nervous system
Multiple sclerosis	60	0.112	0.083	0.177	3.7E−05	−0.023	0.087	0.795
Myasthenia gravis	60	0.104	0.147	0.478	0.17	0.015	0.199	0.939
Neuromyelitis optica	62	−0.439	0.427	0.303	0.17	−0.455	0.574	0.428
Skin
Psoriasis	61	0.190	0.081	0.019	0.19	0.232	0.115	0.044
Vitiligo	57	−0.201	0.151	0.185	1.5E−05	−0.229	0.175	0.189
Vasculitis
Churg Strauss	61	0.007	0.015	0.620	0.40	−0.004	0.021	0.843
Kawasaki	60	0.145	0.214	0.498	0.16	0.324	0.302	0.283
Biomarkers
C-Reactive protein	61	0.090	0.018	4.3E−07	1.8E−25	0.071	0.015	1.38E−06
Interleukin-6	54	0.073	0.025	0.004	0.68	0.056	0.037	0.137
White blood cell count	56	0.037	0.014	0.007	9.9E−20	0.036	0.011	0.002

N SNPs number of single nucleotide polymorphisms used as instruments, IVW Het inverse variance weighted meta-analysis heterogeneity test.

^aBolded where Bonferroni significant.