Table 4.
Somatosensory evoked potentials for patients at baseline, 12 months, and 24 months after AD-MSC injection or right upper, left upper, right lower and left lower limbs at each evaluation
| Patient # | Baseline SSEP | First SSEP after Injection | Final SSEP after Injection | Overall Interpretation |
|---|---|---|---|---|
| Patient 1 |
UE SSEP: Bilateral absolute scalp latencies prolonged. All bilateral interpeak latencies prolonged. LE SSEP: Bilateral absolute scalp latencies prolonged. Bilateral lumbar-to-scalp and left cervical-to-scalp interpeak latencies prolonged. |
Performed at 5 months: UE SSEP: Bilateral absolute scalp latencies prolonged. Bilateral cervical-to-scalp and clavicle-to-scalp interpeak latencies prolonged. LE SSEP: Bilateral absolute scalp latencies prolonged. Bilateral lumbar-to-scalp interpeak latencies prolonged. |
Performed at 18 months: UE SSEP: Bilateral absolute scalp and left absolute cervical latencies prolonged. Bilateral clavicle-to-scalp and left clavicle-to-cervical interpeak latencies prolonged. LE SSEP: Left absolute scalp latency prolonged. Left lumbar-to-scalp interpeak latency prolonged. |
Mild improvement mainly in the right lower extremity SSEPs. |
| Patient 2 |
UE SSEP: Normal left median potentials and latencies. Right median SSEP not performed. LE SSEP: Absent left cervical and scalp potentials. Normal left absolute lumbar potential and latency. Right tibial SSEP not performed. |
Performed at 9 months: UE SSEP: Not performed. LE SSEP: Absent left cervical and scalp potentials. Normal left absolute lumbar potential and latency. No response elicited on the right. |
Performed at 19 months: UE SSEP: Not performed. LE SSEP: No reproducible peripheral or central potentials. |
No reliable interpretation. |
| Patient 3 |
UE SSEP: Bilateral clavicle-to-scalp and clavicle-to-cervical interpeak latencies prolonged. LE SSEP: Normal. |
Performed at 5 months: UE SSEP: Normal. LE SSEP: Normal. |
Performed at 17 months: UE SSEP: Normal. LE SSEP: Normal. |
Improvement in UE SSEP from abnormal at baseline to normal at 5 months. |
| Patient 4 |
UE SSEP: Normal. LE SSEP: Normal. |
Performed at 5 months: UE SSEP: Normal. LE SSEP: Normal. |
Performed at 15 months: UE SSEP: Not performed. LE SSEP: Normal. |
Normal throughout. |
| Patient 5 |
UE SSEP: Not performed. LE SSEP: Bilateral absolute scalp potentials mildly prolonged. Left lumbar-to-scalp interpeak latency borderline prolonged. |
Performed at 5 months: UE SSEP: Not performed. LE SSEP: No reliable information obtained. |
Performed at 17 months: UE SSEP: Not performed. LE SSEP: Normal bilateral absolute lumbar potentials. No other reliable information obtained. |
No reliable interpretation. |
| Patient 6 |
UE SSEP: Right clavicle-to-cervical and left clavicle-to-scalp interpeak latency mildly prolonged. LE SSEP: Normal bilateral lumbar potentials. Normal left cervical absolute and lumbar-to-cervical interpeak latency. No other reliable information obtained. |
Performed at 5 months: UE SSEP: Left clavicle-to-scalp interpeak latency borderline prolonged. Normal right absolute and interpeak latencies. LE SSEP: Normal left cervical and bilateral lumbar absolute latencies. Normal lumbar-to-cervical interpeak latency. No other reliable information obtained. |
Performed at 17 months: UE SSEP: Left clavicle-to-scalp interpeak latency borderline prolonged. Normal right absolute and interpeak latencies. LE SSEP: Normal bilateral lumbar potentials. No other reliable information obtained. |
No significant change from baseline. |
| Patient 7 |
UE SSEP: Normal. LE SSEP: No reliable information obtained. |
Performed at 7 months: UE SSEP: Not performed. LE SSEP: Normal bilateral lumbar absolute latencies. No other reliable information obtained. |
Performed at 17 months: UE SSEP: Not performed. LE SSEP: Normal bilateral absolute lumbar latencies. Right absolute scalp and lumbar-to-scalp interpeak latencies prolonged. |
No reliable interpretation. |
| Patient 8 |
UE SSEP: Left cervical and scalp absolute latencies prolonged. All left interpeak latencies prolonged. Right clavicle-to-scalp interpeak latency prolonged. LE SSEP: No reliable information obtained. |
Performed at 11 months: UE SSEP: Bilateral clavicle-to-cervical and clavicle-to-scalp interpeak latencies prolonged. LE SSEP: No reliable information obtained. |
Performed at 16 months: UE SSEP: Bilateral clavicle-to-scalp interpeak latencies prolonged. Right clavicle-to-cervical interpeak latency prolonged. LE SSEP: Normal left cervical and right lumbar absolute latencies. No other reliable information obtained. |
No change from baseline. |
| Patient 9 |
UE SSEP: Bilateral clavicle-to-scalp and right clavicle-to-cervical interpeak latencies prolonged. LE SSEP: Bilateral lumbar-to-scalp interpeak latency prolonged. |
Performed at 7 months: UE SSEP: Normal. LE SSEP: Left absolute scalp latency normal. No other reliable information obtained. |
Performed at 15 months: UE SSEP: Normal. LE SSEP: Normal bilateral absolute scalp latencies. No other reliable information obtained. |
Resolution of upper extremity central potential prolongation. No reliable interpretation for lower extremities. |
| Patient 10 |
UE SSEP: Normal right absolute clavicle latency. No other reliable information obtained LE SSEP: No reliable information obtained. |
NA | NA | No reliable interpretation. |
Source data are provided as a Source Data file.
All upper extremity studies were performed via stimulation of the median nerve at the wrist, and all lower extremity studies were performed via stimulation of the tibial nerve at ankle.
UE SSEP upper extremity somatosensory evoked potential with median nerve (wrist) stimulation, LE SSEP lower extremity somatosensory evoked potential with tibial nerve (ankle) stimulation, NA not available