Table 1.

Treatment and improvement towards senescent macrophages in degenerations and age-associated diseases.

Treatment	Degenerations/diseases/models	Mechanism	Ref.
Dasastinib & quercetin	BaCl2-induced muscle injury in aged mice	General elimination of senescent cells including senescent macrophages	42
Ganciclovir	Ionizing irradiation-induced senescence in splenic cells	General elimination of senescent cells including senescent macrophages	93
R162	Aged muscle	Inhibition of GLUD1 & promotion of glutamine synthetase activity and improve of infiltration in aged macrophages	102
Niacin	Aged demyelinated mice	Upregulation of CD36 & augment of phagocytosis of aged microglia and macrophages	30
T0-901317	Senescent macrophages from aged mice (>18 months) & aged mice	Downregulation of ABCA1 & restoration of cholesterol efflux in aged macrophages & altered phenotype as M2 macrophages	109
SB265610	Diabetes wound mice	Blockade of CXCR2 & reduction of senescent macrophages & acceleration of skin wound healing	41
Parabiotic coupling young mice M2 macrophages to old mice	CNS demyelination	Increase of M2 macrophages densities & restoration of remyelination efficiency	125
Mesenchymal stem cells	Skin wound mice	Promotion of the conversation of aged macrophage polarization & restoration of tensile strength in aged mice	150
JQ-1	LPS-induced senescent macrophages	Inhibition of BRD4 & decrease of SASP in senescent macrophages	26
Cysteamine	Smase-LDL induced senescent macrophages	Antioxidation of LDL in lysosome & inhibition of secretion of TNF-α, IL-6	166