Fig. 4. Deficiency of CTCF O-GlcNAcylation disturbs a subset of loop domains.

a Overall Hi-C contact probability was not significantly affected. b Hi-C contact maps at 500 kb-resolution across entire chromosome 2 in WT_CTCF (left) and in MUT_CTCF (middle). Compartment scores across entirety of chromosome 2 were remarkably consistent (right). c Compartment scores were not significantly affected genome-wide, Pearson’s r was calculated between WT compartment scores and MUT compartment scores. d Number of loops, loop domains, and differential loop domains. e Samples of enhanced loop domain (left) and weakened loop domain (right). See also Supplementary Fig. 4. Source data are provided as a Source Data file.