Table 3.
Cox Proportional Hazard Models for OS and CSS of patients After PSM.
| Characteristics | OS | CSS | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | HR (95%CI) | |
| Age (Years) | ||||
| 18-44 | Reference | Reference | ||
| 45-54 | 0.97 (0.63-1.49) | 0.901 | 0.93 (0.60-1.45) | 0.760 |
| 55-64 | 0.83 (0.55-1.23) | 0.351 | 0.69 (0.46-1.05) | 0.081 |
| 65-74 | 1.00 (0.65-1.52) | 0.988 | 0.84 (0.54-1.30) | 0.430 |
| ≥75 | 1.31 (0.81-2.13) | 0.269 | 1.00 (0.60-1.68) | 0.992 |
| Gender | ||||
| Male | Reference | Reference | ||
| Female | 0.70 (0.56-0.88) | 0.003 | 0.75 (0.58-0.96) | 0.021 |
| Race | ||||
| White | Reference | Reference | ||
| Black | 1.10 (0.83-1.47) | 0.510 | 1.18 (0.86-1.61) | 0.318 |
| Other | 0.73 (0.58-0.92) | 0.008 | 0.76 (0.59-0.96) | 0.038 |
| Marital status | ||||
| Single | Reference | Reference | ||
| Married | 0.87 (0.70-1.08) | 0.200 | 0.85 (0.68-1.08) | 0.181 |
| Unknown | 0.67 (0.40-1.12) | 0.123 | 0.65 (0.36-1.16) | 0.144 |
| Year of diagnosis | ||||
| 2006-2010 | Reference | Reference | ||
| 2011-2015 | 1.15 (0.94-1.40) | 0.173 | 1.12 (0.90-1.39) | 0.303 |
| AJCC staging | ||||
| I | Reference | Reference | ||
| II | 0.63 (0.25-1.57) | 0.320 | 0.72 (0.28-1.84) | 0.496 |
| III | 1.65 (0.70-3.90) | 0.253 | 2.30 (0.95-5.55) | 0.065 |
| IV | 4.28 (1.17-15.66) | 0.028 | 6.59 (1.65-26.24) | 0.007 |
| Unknown | 0.60 (0.15-2.38) | 0.462 | 2.18 (0.34-14.00) | 0.410 |
| AJCC T | ||||
| T1 | Reference | Reference | ||
| T2 | 2.04 (0.84-4.94) | 0.113 | 1.95 (0.80-4.78) | 0.143 |
| T3 | 0.98 (0.42-2.26) | 0.953 | 0.78 (0.33-1.84) | 0.572 |
| T4 | 1.79 (0.73-4.34) | 0.201 | 1.39 (0.56-3.46) | 0.483 |
| Tx | 1.75 (0.58-5.26) | 0.322 | 0.80 (0.22-2.92) | 0.730 |
| AJCC N | ||||
| N0 | Reference | Reference | ||
| N1 | 0.37 (0.14-0.98) | 0.046 | 0.35 (0.12-1.01) | 0.052 |
| Nx | 1.32 (0.37-4.69) | 0.666 | 0.54 (0.10-2.93) | 0.472 |
| AJCC M | ||||
| M0 | Reference | Reference | ||
| M1 | 0.88 (0.32-2.47) | 0.812 | 0.70 (0.23-2.10) | 0.525 |
| Tumor size (cm) | ||||
| ≤2 | Reference | Reference | ||
| >2, ≤5 | 1.32 (0.91-1.91) | 0.148 | 1.18 (0.79-1.78) | 0.426 |
| >5, ≤10 | 1.43 (0.96-2.14) | 0.079 | 1.36 (0.88-2.11) | 0.166 |
| >10 | 2.06 (1.36-3.12) | 0.001 | 2.02 (1.29-3.17) | 0.002 |
| Unknown | 1.89 (1.00-3.58) | 0.049 | 1.76 (0.86-3.68) | 0.123 |
| Tumor number | ||||
| 1 | Reference | Reference | ||
| 2 | 0.74 (0.56-0.97) | 0.032 | 0.65 (0.47-0.83) | 0.008 |
| 3 | 1.32 (0.78-2.25) | 0.299 | 0.92 (0.46-1.84) | 0.812 |
| >3 | 1.00 (0.36-2.78) | 0.996 | 0.37 (0.05-2.73) | 0.332 |
| Radiation | ||||
| No/Unknown | Reference | Reference | ||
| Yes | 1.07 (0.70-1.63) | 0.743 | 1.15 (0.73-1.80) | 0.546 |
| Chemotherapy | ||||
| No | Reference | Reference | ||
| Yes | 1.62 (0.59-4.46) | 0.348 | 2.65 (0.64-10.93) | 0.177 |
| Surgery | ||||
| Liver resection | Reference | Reference | ||
| Transplantation | 0.62 (0.48-0.80) | <0.001 | 0.57 (0.43-0.76) | <0.001 |
| Systemic Sur Seq | ||||
| Before-surgery | Reference | Reference | ||
| After-surgery | 1.81 (1.49-2.20) | <0.001 | 1.96 (1.58-2.43) | <0.001 |