Table 4.
The relationship between the sequence of treatment modalities (systemic treatment and surgery) and OS and CSS.
| Non-adjusted | Adjust I a | Adjust II b | Adjust III c | Post-PSM | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | ||
| OS | pre-surgery | reference | reference | reference | reference | reference | |||||
| post-surgery | 3.24 (2.84-3.71) |
<0.001 | 3.06 (2.66-3.52) |
<0.001 | 2.34 (2.01-2.72) |
<0.001 | 1.84 (1.55-2.17) |
<0.001 | 1.74 (1.44-2.09) |
<0.001 | |
| CSS | pre-surgery | reference | reference | reference | reference | reference | |||||
| post-surgery | 4.31 (3.69-5.03) |
<0.001 | 4.01 (3.41-4.70) |
<0.001 | 2.90 (2.44-3.45) |
<0.001 | 2.10 (1.73-2.54) |
<0.001 | 1.86 (1.52-2.29) |
<0.001 | |
a. Adjust I: Adjusted basic demographic information (Gender, Martial, Race, Age).
b. Adjust II: Adjusted basic demographic and fundamental oncological information (Gender, Martial, Race, Age, Year of diagnosis, AJCC staging, AJCC T/N/M, Tumor size, Tumor number).
c. Adjust III: Adjusted basic demographic, fundamental oncological, and treatment information (including all incorporated variables).