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. 2024 Mar 19;11:1374843. doi: 10.3389/fmolb.2024.1374843

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Copyright © 2024 Hynes and Kakumani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RBPs involved in the processing of pri-miRNA in the nucleus. The microprocessor complex, consisting of Drosha and DGCR8 proteins, associates with pri-miRNA through their RNA binding domains and recognition of sequence motifs. Different RBPs also associate with different sequence elements of pri-miRNA: (A) SRSF3 promotes microprocessor-mediated pri-miRNA cleavage, (B) KSRP promotes microprocessor-mediated cleavage of pri-miR-196a, pri-miR-155, and pri-let-7, (C) hnRNPA1 promotes microprocessor-mediated cleavage of pri-miR-18a, (D) hnRNPA1 hinders microprocessor-mediated cleavage of pri-let-7a, (E) TDP-43 promotes microprocessor-mediated cleavage of pri-miR-143 and pri-miR-574, (F) LIN28B inhibits microprocessor-mediated cleavage of pri-let-7, (G) HuR and MSI2 inhibit microprocessor-mediated cleavage of pri-miR-7, (H) YB-1 inhibits microprocessor-mediated cleavage of pri-miR-29b-2, (I) Matr3 inhibits microprocessor-mediated cleavage of pri-miR-138-2, (J) EWS promotes microprocessor-mediated cleavage of pri-miR-34a, pri-miR-122, and pri-miR-222, (K) QKI5 promotes microprocessor-mediated cleavage of pri-miR-124-1 through recruitment to a distal QRE sequence and subsequent RNA folding to bring the microprocessor to the appropriate location, (L) SYNCRIP promotes microprocessor-mediated cleavage of pri-let-7a.