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. 2024 Mar 19;11:1374843. doi: 10.3389/fmolb.2024.1374843

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Copyright © 2024 Hynes and Kakumani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cluster assistance phenomenon for sub-optimal processing of pri-miRNAs (A,B) The processing of pri-miR-451 and pri-miR-15a depends on their transcript neighbours, pri-miR-144 and pri-miR-16-1, which recruit the microprocessor to pri-miR-451 and pri-miR-15a, respectively, with the assistance of SAFB2 and ERH. (C) pri-miR-998 processing depends on transcript neighbour, pri-miR-11, which helps recruit the microprocessor to pri-miR-998. (D) In Epstein-Barr Virus, pri-miR-BHRF1-3 processing depends on transcript neighbour, pri-miR-BHRF1-2, which helps recruit the microprocessor to pri-miR-BHRF1-3 for the generation of respective pre-miRNAs.