. 2024 Mar 19;15:1366377. doi: 10.3389/fimmu.2024.1366377

Table 1.

Expression of IL-27 in inflammatory autoimmune diseases.

Disease	Sample	Expression	Treatment	Ethnicity	Reference
SLE	Serum	Reduced ^a	Steroids, Antimalarial agents, Azathioprine, Micophenolate mofetil, Thalidomide	Brazilian	(119)
	Serum	Reduced ^a	Corticosteroid	Southern Chinese	(120)
	Serum, urine	Increased ^a	None	Northern Chinese	(121)
	PBMC	Increased ^a	None	North American	(122)
RA	Plasmablast, serum, Breg cell	Increased ^a	None	Northern Chinese	(123)
	Serum	Increased ^a	None	Southern Chinese, Northern Chinese	(124, 125)
	Plasma	Increased ^a	None	Southern Chinese	(126)
	Synovium, synovial fluid	Increased ^a	None	Japanese	(127)
	Synovitis	Reduced ^a	Methotrexate	UK	(128)
SS	Serum	Increased ^a	Unknown	Northern Chinese	(129)
	Serum, salivary glands	Increased ^a	Unknown	UK	(130)
	PBMC, serum	Reduced ^a	Prednisone, Hydroxychloroquine, Cyclophosphamine, Leflunomide	Southern Chinese	(131)
	Serum	Reduced ^b	None	–	(131)
	Plasma	Reduced ^a	Unknown	Northern Chinese	(132)
BD	Serum	Reduced ^a	Unknown	Turkish	(133)
	Serum, PBMC	Reduced ^a	None	Southern Chinese	(134)
	Serum	Increased ^a	Prednisone	Southern Chinese	(135)
	Serum	Increased ^a	None	Iranian	(136)
IBD	PBMC	Normal ^a	5-aminosalicylic acid, Prednisone, Azathioprine (AZA), Infliximab	Iranian	(137)
	Colonic biopsy	Increased ^a	Mesalazine, Azathioprine, Prednisone, Mercaptopurine	Mexican	(138)
	Colonic mucosa	Increased ^a	Steroids, Azathioprine	German	(139)
	Intestinal mucosa	Increased ^a	Mesalazine, Corticosteroids, Methotrexate, Azathioprine	German	(140)
	Serum, stool, moDC	Increased ^a	Unknown	Southern Chinese	(141)
	Serum, cecum	Increased ^b	None	–	(141)
MS	Serum	Reduced ^a	None	Romanian, Northern Chinese, Iranian	(142–144)
	Serum, cerebrospinal fluid	Increased ^a	Corticoids	Swiss	(145)
	Plasma	Increased ^a	INFβ	Iranian	(146)
	Serum, cerebrospinal fluid	Increased ^a	Unknown	Canadian	(147)
	Serum	Increased ^b	Unknown	–	(148)
	Brain tissue	Increased ^a	Unknown	Canadian	(149)
Psoriasis	Serum	Increased ^a	None	Brazilian	(150)
	Serum	Increased ^a	Steroids, Vitamin D3	Japanese	(151)
	Serum, epidermis, dermis, PBMC	Reduced ^a	None	Southern Chinese	(152)
SSc	Serum, B cell, CD4⁺ T cell	Increased ^a	None	Japanese	(153)
T1D	Serum	Normal ^a	None	Polish	(154)
	Serum	Reduced ^a	Insulin	Iranian	(155)
	Plasma	Increased ^a	Insulin	Estonian	(156)
	Treg cell	Reduced ^a	Insulin	Polish	(157)
VKH	Serum, PBMC	Reduced ^a	None	Southern Chinese	(158)
VKH	Serum	Increased ^a	None	Southern Chinese	(159)
AS	Serum, synovial fluid	Increased ^a	Unknown	Northern Chinese	(160)

SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; SS, Sjogren syndrome; BD, Behcet’s disease; IBD, inflammatory bowel disease; MS, multiple sclerosis; SSc, systemic sclerosis; T1D, type 1 diabetes; VKH, Vogt–Koyanagi–Harada; AS, ankylosing spondylitis; PBMC, peripheral blood mononuclear cells; Breg cell, regulatory B cell; moDC, monocyte-induced dendritic cell; Treg cell, regulatory T cell.

Human.

Mice.