Figure 3.

Benchmark for fusion gene detection using simulated fusion transcripts

We simulated fusion gene bRNA-seq data with varying coverage and applied multiple fusion detection tools to identify supporting evidences for fusion genes. The x axis represents the ratio of simulated transcript base pairs to fusion gene base pairs.

(A)–(F) represent specific fusion genes, and the fusion breakpoints are annotated with GRCh38. The left section of the subgraph depicts all support evidences, and the y axis represents the logarithm base 2 of the quantity of evidences. The middle section corresponds to spanning evidences, while the right section represents split evidences. The y axis indicates the ratio of detected supporting evidences for each tool compared to the maximum supporting evidences among them.