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. 2024 Mar 19;11:1277818. doi: 10.3389/fmolb.2024.1277818

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Copyright © 2024 Ge, Cai, Cai, Mou, Fu and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of hub genes. (A) Differences in expression levels of BHLHE40, CASP4, PECAM1, PKM, SERPINB1, TLR2, and VEGFA in the control (green) and aortic dissection (AD, orange) groups. (B) Functional similarity analysis of key genes. (C–I) Receiver operating characteristic (ROC) curves for CASP4 (C), PECAM1 (D), PKM (E), SERPINB1 (F), TLR2 (G), VEGFA (H), and BHLHE40 (I). The horizontal coordinate is 1—specificity and the vertical coordinate is sensitivity; AUC, area under the curve, with an AUC value closer to 1 indicating better diagnostic prediction ability. (ns: p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).