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. 2024 Mar 19;15:1342965. doi: 10.3389/fphar.2024.1342965

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Copyright © 2024 Fichera, Nanetti, Monelli, Castaldo, Marchini, Neri, Vukaj, Marzorati, Porcelli and Mariotti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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One-year longitudinal changes in Friedreich patients Graph displays the percentages of variations in clinical and digital measures at follow-up compared to baseline. All clinical scale scores increased at follow-up indicating a worsening of ataxia severity: SARA (Scale for the Assessment and Rating of Ataxia); mFARS (modified Friedreich Ataxia Rating Scale); and ADL (Activity of Daily Living part II of FARS scale). Accelerometer digital measures showed a reduction in daily-life motor activities, as indicated by the decreased percentage of light and moderate-vigorous activities (MVPA) and in vector magnitude. Error bars indicate standard error; *p < 0.05 at paired-statistical test comparing follow-up and baseline data for.