Table 1.

hMAO inhibitory potency and selectivity of identified compounds.

Compounds	Inhibition (IC50)a		SIb
	hMAO-B	hMAO-A
(Z)-Ligustilide	633.346 ± 341.181	6.063 ± 0.985	0.009
Senkyunolide H	593.668 ± 55.172	107.921 ± 11.931	0.182
Senkyunolide I	302.342 ± 37.001	186.240 ± 8.010	0.616
n-Butylphthalide	112.552 ± 24.240	19.180 ± 3.759	0.170
Chlorogenic acid	69.634 ± 14.365	82.362 ± 14.569	1.183
Vanillin	45.695 ± 2.605	86.090 ± 15.313	1.884
Caffeic acid	33.093 ± 7.566	60.901 ± 5.847	1.840
Sinapic acid	32.783 ± 6.098	32.899 ± 5.705	1.004
Senkyunolide A	27.029 ± 9.316	47.573 ± 8.511	1.760
Ferulic acid	26.899 ± 3.528	35.828 ± 2.228	1.332
Butylidenephthalide	12.123 ± 6.480	96.986 ± 14.286	8.000
Coniferyl ferulate	2.029 ± 0.347	102.439 ± 1.331	50.487
Neocnidilide	0.494 ± 0.132	102.437 ± 13.108	207.362
Sedanolide	0.124 ± 0.033	80.067 ± 15.103	645.702
Rasagiline	0.114 ± 0.015	3.564 ± 0.386	31.263
Safinamide	0.006 ± 0.005	104.202 ± 34.732	17,367
Toloxatone	357.219 ± 22.843	1.438 ± 0.162	0.004

^aInhibition data are reported as IC₅₀ (μmol/L); the standard error of the mean was always less than ± 5%.

^bSI: selectivity index for the MAO-B isoform, equal to the ratio of IC₅₀(MAO-A)/IC₅₀(MAO-B).