Figure 4.

Schizophrenia application

(A) Dendrogram representation of hierarchical clustering applied on the SPIT DTU matrix for schizophrenia samples.

(B) SPIT-Chart for the schizophrenia analysis. For each transcript that passed the initial filtering steps, the median p value that has been observed through 100 iterations of the SPIT-Test $\left(\text{median}\left(\bigcup _S{p}_{j,s}\right)\right)$ is plotted on the x axis, and the p value observed in the actual comparison of the schizophrenia samples with the controls is plotted on the y axis, both on $-{\mathit{log}}_{10}$ scale.

(C) Boxplots of permutation importance scores (generated from 100 permutations) of the SPIT output vector and provided covariates for the final 6 DTU genes.