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. Author manuscript; available in PMC: 2024 Apr 2.
Published in final edited form as: J Neurosurg. 2017 Apr 7;128(2):380–390. doi: 10.3171/2016.10.JNS161636

FIG. 2.

FIG. 2.

Case 22. Convexity meningioma displaying inverted fluorescence signal. Axial (A) and coronal (B) contrast-enhanced T1-weighted MR images. In the visible-light view (C), the brain parenchyma can be identified and the tumor is just starting to be seen as the dura is peeled back. The NIR fluorescence superimposed and color-mapped onto the visible-light view (D) demonstrates an inverted pattern with more NIR signal in adjacent brain parenchyma than in tumor. The SBR of NIR tumor signal is 0.30. When tumor was removed from the patient (E), there was still accumulation of 125IR dye within the meningioma as compared with the attached dura (F). Ex vivo analysis confirms the presence of residual dye within tumor.