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The flowchart of two-sample and two-step mendelian randomization evaluating the effects of inflammation biomarkers in mediating the effect of SGLT-2 inhibition on heart failure. HbA1c glycated hemoglobin, GWAS genome-wide association study, pQTL protein quantitative trait loci SNP single nucleotide polymorphism, LD linkage disequilibrium, CRP C-reactive protein, SGLT-2 sodium-glucose Cotransporter-2
