Skip to main content
. 2024 Apr 2;23:118. doi: 10.1186/s12933-024-02210-5

Table 1.

MR estimates of the effect of SGLT2 inhibition on heart failure

Method Number of SNPs OR (95% CI) P value Q statistic P-heterogeneity Egger-intercept P-intercept
Inverse variance weighted 14 0.42(0.30–0.59) 0.0000 9.5282 0.7320
MR egger 14 0.36(0.09–1.48) 0.1814 9.4818 0.6613 0.0021 0.8331
Simple mode 14 0.47(0.23–0.96) 0.0590
Weighted median 14 0.46(0.29–0.72) 0.0007
Weighted mode 14 0.44(0.23–0.83) 0.0242
MR-PRESSO 14 0.42(0.31–0.56) 0.0000 10.6687 0.8170

The heterogeneity test in the IVW methods was performed using Cochran’s Q statistic and the global test for the MR-PRESSO method. P < 0.05 was considered significant

OR Odds ratio, CI 95% confidence interval, IVW inverse–variance weighted, P-heterogeneity P value for heterogeneity test, P-intercept P value for the intercept of MR-Egger regression