Table 1.
Method | Number of SNPs | OR (95% CI) | P value | Q statistic | P-heterogeneity | Egger-intercept | P-intercept |
---|---|---|---|---|---|---|---|
Inverse variance weighted | 14 | 0.42(0.30–0.59) | 0.0000 | 9.5282 | 0.7320 | ||
MR egger | 14 | 0.36(0.09–1.48) | 0.1814 | 9.4818 | 0.6613 | 0.0021 | 0.8331 |
Simple mode | 14 | 0.47(0.23–0.96) | 0.0590 | ||||
Weighted median | 14 | 0.46(0.29–0.72) | 0.0007 | ||||
Weighted mode | 14 | 0.44(0.23–0.83) | 0.0242 | ||||
MR-PRESSO | 14 | 0.42(0.31–0.56) | 0.0000 | 10.6687 | 0.8170 |
The heterogeneity test in the IVW methods was performed using Cochran’s Q statistic and the global test for the MR-PRESSO method. P < 0.05 was considered significant
OR Odds ratio, CI 95% confidence interval, IVW inverse–variance weighted, P-heterogeneity P value for heterogeneity test, P-intercept P value for the intercept of MR-Egger regression