Table 2.
Impact of SGLT-2 Inhibition on inflammatory biomarkers
| Variants | OR (95% CI) | P value | FDR adjusted P value |
|---|---|---|---|
| CCL19 | 1.85 (1.10–3.12) | 0.0199 | 0.0678 |
| CCL20 | 2.84 (1.69–4.76) | 0.0001 | 0.0014 |
| CCL28 | 1.89 (1.15–3.12) | 0.0125 | 0.0499 |
| CD5 | 4.01 (2.40–6.69) | 0.0000 | 0.0000 |
| CXCL10 | 0.55 (0.33–0.93) | 0.0245 | 0.0750 |
| CXCL6 | 2.36 (1.40–3.95) | 0.0012 | 0.0092 |
| CXCL9 | 0.51 (0.28–0.91) | 0.0223 | 0.0734 |
| DNER | 0.35 (0.19–0.65) | 0.0010 | 0.0086 |
| Protein S100-A12 | 1.82 (1.09–3.05) | 0.0232 | 0.0737 |
| FGF19 | 2.72 (1.63–4.54) | 0.0021 | 0.0149 |
| FGF21 | 1.78 (1.06–2.99) | 0.0297 | 0.0881 |
| FGF23 | 0.37 (0.22–0.62) | 0.0001 | 0.0020 |
| IFN-Y | 0.47 (0.27–0.84) | 0.0110 | 0.0482 |
| IL-10 | 2.29 (1.36–3.85) | 0.0017 | 0.0121 |
| IL12B | 3.78 (2.22–6.45) | 0.0000 | 0.0000 |
| IL-22RA | 2.72 (1.51–4.88) | 0.0008 | 0.0074 |
| IL-6 | 1.99 (1.19–3.33) | 0.0086 | 0.0416 |
| LAP TGF-B1 | 3.35 (1.76–6.40) | 0.0002 | 0.0025 |
| LIF | 0.48 (0.27–0.86) | 0.0135 | 0.0518 |
| MCP-1 | 1.98 (1.19–3.32) | 0.0091 | 0.0416 |
| MCP-4 | 2.02 (1.21–3.38) | 0.0074 | 0.0380 |
| Neurturin | 0.49 (0.27–0.87) | 0.0150 | 0.0553 |
| PD-L1 | 0.36 (0.21–0.59) | 0.0001 | 0.0014 |
| SULT1A1 | 0.35 (0.17–0.75) | 0.0068 | 0.0367 |
| TNF | 0.48 (0.27–0.85) | 0.0125 | 0.0499 |
| TSLP | 2.00 (1.12–3.59) | 0.0198 | 0.0678 |
| uPA | 2.19 (1.31–3.66) | 0.0029 | 0.0176 |
| CRP | 0.88 (0.80–0.96) | 0.0058 | 0.0334 |
CI confidence interval, OR odds ratio, CCL19 C–C motif chemokine 19, CCL20 C–C motif chemokine 20, CCL28 C–C motif chemokine 28, CXCL10 C-X-C motif chemokine 10, CXCL6 C-X-C motif chemokine 6, CXCL9 C-X-C motif chemokine 9, DNER Delta and Notch-like epidermal growth factor related receptor, FGF19 Fibroblast growth factor 19, FGF21 Fibroblast growth factor 21, FGF23 Fibroblast growth factor 23, IFN-γ Interferon gamma, IL-10 Interleukin-10, IL-12B Interleukin-12 subunit beta, IL-22RA Interleukin-22 receptor subunit alpha-1, IL-6 Interleukin-6, LAP TGF-β1 Latency associated peptide transforming growth factor beta 1, LIF Leukemia inhibitory factor, MCP -1 Monocyte chemoattractant protein-1, MCP-4 Monocyte chemoattractant protein-4, PD-L1 Programmed cell death 1 ligand 1, SULT1A1 Sulfotransferase 1A1, TNF Tumor necrosis factor, TSLP Thymic stromal lymphopoietin, uPA Urokinase type plasminogen activator, CRP C-reactive protein