TABLE 3.
Virulome of the sequenced MRSA that causes invasive infection in Paraguayan children (n = 10)a
| Protein type/function | Antiphagocytic | Pore-forming exotoxins | Adherence | Exoenzyme | Toxins | Evasins | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID sample CC-ST-spatype |
CP | SSP | SAPM | CI | ECDI | PVL | Hemolysin | BFG | SF | CF | TGD | SA | SP |
| SGP11 CC30-ST30-t019 |
cap8A/B/C/D/E/
F/G/H/I/J/K |
– | adsA | Chp | – |
lukF-PV,
lukS-PV |
hlb, hld |
icaA, icaB, icaC, icaD,
icaR |
sdrC, sdrE, cna,
fnbA, map |
clfB, vWbp | lip |
seg, sem, sen, seo, seu |
splE |
| SIP29 CC30-ST30-t019 |
cap8A/B/C/D/E/
F/G/I/J/K |
– | adsA | – | – |
lukF-PV,
lukS-PV |
– |
icaA, icaB, icaC, icaD,
icaR |
sdrC, sdrE, cna, fnbA, map | clfB, vWbp | lip | seg, sem, seo | splE |
| SGP29 CC5-ST5-t311 |
cap8A/B/C/D/E/
F/G |
esaC, essC, esxB | adsA | Chp | edinA |
lukF-PV,
lukS-PV |
hlb, hld, hly/hla |
icaA, icaB, icaC, icaD,
icaR |
sdrC, sdrD, sdrE, fnbA,
fnbB, map |
clfB | lip |
sea, seg, sei, sem,
sen, seo, seu |
splA, splB |
| SGP63 CC8-ST8-t11770 |
cap8A/B/C/D/E/
F/G |
esaC, essC, esxB | adsA | Chp | – |
lukF-PV,
lukS-PV |
hlb, hld |
icaA, icaB, icaD, icaR |
sdrC, sdrD, sdrE, fnbA,
fnbB |
clfB | lip | sek, seq | splA, splB, splE |
| SGP102 CC30-ST30-t019 |
cap8A/B/C/D/E/
F/G/H/I/J/K |
– | adsA | Chp | – |
lukF-PV,
lukS-PV |
hlb, hld, hly/hla |
icaA, icaB, icaC, icaD,
icaR |
sdrC, sdrD, sdrE, map | clfB, vWbp | lip |
seg, sei, sem,
sen, seo, seu |
splE |
| SCM71 CC5-ST100-t002 |
cap8A/B/C/D/E/
F/G |
esaC, essC, esxB | adsA | – | – | lukF-PV | hlb, hld, hly/hla |
icaA, icaB, icaC, icaD,
icaR |
sdrC, sdrD, sdrE, fnbA,
fnbB |
clfB | lip |
seg, sei, sen,
seo, seu |
splA, splB |
| SCM77 CC5-ST5-t311 |
cap8A/B/C/D/E/
F/G |
esaC, essC, esxB | adsA | Chp | edinA |
lukF-PV,
lukS-PV |
hlb, hld, hly/hla |
icaA, icaB, icaC, icaD,
icaR |
sdrC, sdrD, sdrE, fnbA,
fnbB, map |
clfB | lip |
sea, seg, sei, sem,
sen, seo, seu |
splA, splB |
| SHN80 CC30-ST30-t021 |
cap8I/J/K | – | adsA | Chp | – | – | hlb, hld, hly/hla |
icaA, icaB, icaC, icaD,
icaR |
sdrE | clfB, vWbp | lip, |
sea, seg,sei, sem,
sen, seo, seu, tsst-1 |
splE |
| GIP4 CC8-ST8-t400 |
cap8A/B/C/D/F/
G |
esaC, essC, esxB | – | Chp | – |
lukF-PV,
lukS-PV |
hlb, hld | – |
sdrC, fnbA,
fnbB, map |
coa, vWbp | – | seg, sek, seq | splA, splB, splE |
| GIP64 CC30-ST30-t019 |
cap8A/B/C/D/E/
F/G/H/I/J/K |
– | adsA | Chp | – |
lukF-PV,
lukS-PV |
hlb, hld, hly/hla |
icaA, icaB, icaC, icaD,
icaR |
fnbA | vWbp | lip |
seg, sei, sem,
sen, seo, seu |
splE |
a
(–), gene not detected by WGS; ID, identification; CC, clonal complex; ST, sequence type; CP, capsular polysaccharide; SSP, secretion system protein; SAPM, synthases of anti-phagocytic mediators; CI, chemotaxis-inhibiting; ECDI, epidermal cell differentiation inhibitor; PVL, Panton-Valentine leucocidin; BFG, biofilm formation genes; SF, surface proteins; CF, coagulation factors; TGD, triacylglycerol degradation; SA, superantigens; and SP, serine proteases.