Table 7.
Factors associated with white matter brain injury on multivariable logistic regression analysis.
| Variable | Factors associated with any white matter brain injury (present vs. absent) |
Factor associations with Gade 3 or 4 white matter brain injury (present vs. absent) |
Factor associations with white matter brain injury (ordinal levels) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p | Odds ratio | 95% CI | p | Odds ratio | 95% CI | p | ||||
| AKI by serum creatinine (Stage 2/3 vs. Stage 1 or normal) | 12.9 | 0.7 | 241 | 0.087 | 9.8 | 0.8 | 116 | 0.072 | 6.2 | 1.1 | 35.5 | .041 |
| Indomethacin use (vs. not use) | 0.5 | 0.1 | 12.9 | 0.706 | 2.1 | 0.1 | 46.2 | 0.633 | 0.6 | 0.1 | 4.9 | .666 |
| Birth weight (g) | 6.7 | 1.0 | 44.5 | 0.092 | 3.6 | 0.5 | 44.5 | 0.161 | 3.6 | 1.0 | 12.6 | .072 |
| Length of bowel resected (cm) | 0.5 | 0.06 | 4.8 | 0.562 | 0.6 | 0.1 | 4.8 | 0.588 | 0.4 | 0.1 | 1.8 | .251 |
| Post-operative days at starting enteral feedings (days) | 2.8 | 0.5 | 15.7 | 0.240 | 4.8 | 0.9 | 25.3 | 0.069 | 2.6 | 0.8 | 8.3 | .097 |
| Day of attainment of full enteral feedings (120 mL/kg) | 1.6 | 0.5 | 5.2 | 0.386 | 1.7 | 0.5 | 5.9 | 0.378 | 1.8 | 0.9 | 3.8 | .112 |
| 24 h Pressor support, n (%) | 35.8 | 0.7 | >999.9 | 0.073 | 5.0 | 0.1 | 210 | 0.396 | 15.9 | 1.1 | 231 | .043 |
| CRP at 24 h after NEC onset | 0.8 | 0.2 | 3.2 | 0.766 | 0.5 | 0.1 | 1.7 | 0.268 | 0.9 | 0.4 | 2.2 | .835 |
| Age of NEC onset (days) | 1.2 | 0.4 | 3.8 | 0.766 | 3.1 | 0.9 | 10.4 | 0.068 | 1.3 | 0.6 | 2.8 | .544 |
| Length of stay (days) | 4.9 | 0.7 | 35.6 | 0.100 | 3.5 | 0.5 | 25.7 | 0.213 | 3.3 | 1.0 | 9.6 | .042 |
Odds ratio for continuous variables are expressed per standard deviation of that factor.
The bold value signifies the p value is less than 0.05.