Comparison 3. Subgroup analyses: ITT analysis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Graft loss: censored for death	17	2540	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.62, 0.99]
1.1 ITT analysis performed	10	2132	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.65, 1.08]
1.2 ITT analysis unclear	7	408	Risk Ratio (M‐H, Random, 95% CI)	0.50 [0.26, 0.93]
1.3 ITT analysis not performed	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2 Acute rejection: total	22	3301	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.57, 0.73]
2.1 ITT analysis performed	12	2757	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.58, 0.75]
2.2 ITT analysis unclear	8	470	Risk Ratio (M‐H, Random, 95% CI)	0.53 [0.34, 0.84]
2.3 ITT analysis not performed	2	74	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.16, 1.85]
3 Infection: CMV viraemia/syndrome	13	2880	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.85, 1.32]
3.1 ITT analysis performed	10	2691	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.83, 1.34]
3.2 ITT analysis unclear	2	148	Risk Ratio (M‐H, Random, 95% CI)	1.47 [0.13, 16.10]
3.3 ITT analysis not performed	1	41	Risk Ratio (M‐H, Random, 95% CI)	1.18 [0.33, 4.29]
4 Graft function: serum creatinine	15	2233	Mean Difference (IV, Random, 95% CI)	0.05 [‐0.05, 0.15]
4.1 ITT performed	10	1948	Mean Difference (IV, Random, 95% CI)	0.07 [‐0.03, 0.17]
4.2 ITT unclear	4	252	Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.45, 0.16]
4.3 ITT not performed	1	33	Mean Difference (IV, Random, 95% CI)	‐0.16 [‐1.25, 0.93]