Comparison 4. Subgroup analyses: adults only versus children included.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Graft loss: censored for death	17	2540	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.62, 0.99]
1.1 Adults only	6	1676	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.64, 1.10]
1.2 Children included	2	324	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.10, 3.15]
1.3 No details reported	9	540	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.28, 0.95]
2 Acute rejection: total	22	3301	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.57, 0.73]
2.1 Adults only	8	2292	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.57, 0.79]
2.2 Children included	2	324	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.46, 1.04]
2.3 No details reported	12	685	Risk Ratio (M‐H, Random, 95% CI)	0.53 [0.40, 0.71]
3 Infection: CMV viraemia/syndrome	13	2880	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.85, 1.32]
3.1 Adults only	7	2246	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.84, 1.45]
3.2 Children included	2	324	Risk Ratio (M‐H, Random, 95% CI)	1.60 [0.62, 4.09]
3.3 No details reported	4	310	Risk Ratio (M‐H, Random, 95% CI)	0.82 [0.54, 1.24]
4 Graft function: serum creatinine	15	2233	Mean Difference (IV, Random, 95% CI)	0.05 [‐0.05, 0.15]
4.1 Adults only	7	1772	Mean Difference (IV, Random, 95% CI)	0.06 [‐0.06, 0.19]
4.2 Children included	1	100	Mean Difference (IV, Random, 95% CI)	0.0 [‐0.26, 0.26]
4.3 No details reported	7	361	Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.24, 0.22]