Table 1.

Association of CAD (status and time of the diagnosis) with PCL total scores in MVP and UKB.

CAD	MVP (PCL-17; control N = 245,962)							UKB (PCL-6, control N = 146,875)
	case N	Case-Control			Case-only			case N	Case-Control			Case-only
		Beta	SE	P	Beta	SE	P		Beta	SE	P	Beta	SE	P
Total sample	73,074	2.89	0.06	< 10−300	0.112	0.01	4.08 × 10−29	8942	0.58	0.034	3.98 × 10−66	0.01	0.004	0.001
Onset after PCL assessment	12,267	2.19	0.13	1.12 × 10−63	0.192	0.075	0.011	167	0.25	0.234	0.391	−0.57	0.533	0.287
Onset same-year PCL assessment	4646	2.71	0.21	4.23 × 10−38	−	−	−	590	0.44	0.125	3.94 × 10−4	−	−	−
Onset before PCL assessment	56,161	3.03	0.07	< 10−300	0.11	0.014	6.95 × 10−16	8185	0.6	0.035	7.11 × 10−66	0.011	0.005	0.027

In the case-control analysis, the PCL total scores of controls were compared with those of CAD cases (total sample and stratified by the timing of their cardiac disease onset with respect to PCL assessment). In the case-only analysis, we tested the association of PCL total scores with the temporal difference (years) between the time of CAD diagnosis and the time of PCL assessment. In MVP, the analyses were corrected for age, sex, income, self-reported ethnicity, and self-reported racial background. In UKB, the analyses were corrected for age, sex, Townsend deprivation index, and self-reported ethnic background.