Table 1.
Basic information regarding included studies.
| Study, year | Age (years) (PCC/Non-PCC) | Female (PCC/Non-PCC) | Sample (PCC/Non-PCC) | BMI (PCC/Non-PCC) | Types of cardiac surgery | PCC group | Non-PCC group |
|---|---|---|---|---|---|---|---|
| Biancari, 2019 | 65.9 (6.7)/65.3 (9.3) | 14-nov. | 101/101 | 27.4 (4.3)/27.1 (3.9) | CABG | PCC: initial dose was 1,000 IU (2,000-3,000 IU) | Fresh frozen plasma with non-PCC |
| Bradford, 2015 | 68/69 | 3-mai. | 41/27 | NA | CABG | PCC: 500 units, every 30 min., maximum dose of 25 units/kg | Non-PCC |
| Cappabianca, 2016 | 69.7 (10.6)/69.2 (11.6) | 91/91 | 225/225 | 24 (4.9)/25 (4.7) | CABG, valve surgery, and proximal aortic procedures | PCC: 500 IU | Non-PCC |
| Fitzgerald, 2018 | 61 (46-70)/60 (50-69) | 45/40 | 117/117 | NA | Valve or isolated CABG | PCC: 15-25 lU/kg in 1000 IU increments | Frozen plasma with non-PCC |
| Green, 2020 | 69 (63-73)/66 (57-74) | 9-set. | 21/21 | 27 (6)/29 (5) | Valve only, major aortic valve only, CABG plus valve, complex/combined procedure | <60 kg: 500 IU; 61-90 kg: 1000 IU; and > 90 kg: 1500 IU | Fresh frozen plasma with non-PCC |
| Harper, 2018 | 60.9 (17.4)/58.5 (19.7) | 17/18 | 53/53 | NA | Mechanical circulatory support, valve transplant, aorta resection plus CABG/valve (s), aorta resection, CABG plus valve (s), congenital/ conduit, CABG, pericardiectomy | Factor IX complex | rFVIIa |
| Harris, 2020 | 65.7 (59-77)/66.9 (59-73) | mai.-19 | 19/60 | 28.7 (24.5-34.3)/29.7 (25.1-33.3) | Isolated CABG, isolated valve | 4-factor PCC: 11.5 (5.3-39.3) units/kg | Non-4-factor PCC |
| Karkouti, 2020 | 66 (50-73)/67 (55-74) | 14/14 | 54/47 | 23.6 (4.5)/23.1 (4.7) | Cardiac surgery | PCC: 1500 IU for patients weighing ≤ 60 kg and 2000 IU for patients weighing > 60 kg | Frozen plasma with non-PCC |
| Ortmann, 2014 | 61 (13)/62 (13) | 19/18 | 45/55 | 28.8(6.1)/27.3(5.0) | Complex cardiac surgery | PCC:15 IU/kg to the nearest 250 IU vial | Fresh frozen plasma with non-PCC |
| Tanaka, 2013 | 55.5 (16.6)/57.8 (12.6) | 15/30 | 50/100 | NA | Valve, aortic, transplant or ventricular assist device implantation | 3-factor PCC: 25 lU/kg, Bebulin or Profilnine upon availability | rFVIIa |
| Zweng, 2018 | 66.9 (12.18)/69.4 (10.5) | 25/34 | 80/80 | NA | CABG, valve, other | The amount of PCC: 500 to 9000 IU | Fresh frozen plasma with non-PCC |
| Alyson, 2021 | 65 (57-73) /69 (58-78) | 21-set. | 61/46 | 25.2 (22.5-29.1)/25 (23-28) | CABG, multivalve procedure, single-valve procedure, CABG and valve, aortic procedure, aortic dissection, ventricular septal defect repair | 4-factor PCC | rFVIIa |
BMI=body mass index; CABG=coronary artery bypass grafting; IU=international units; NA=not available; PCC=prothrombin complex concentrate; rFVIIa=recombinant factor Vlla