Table 1. Main features of human (LNCaP and PC3) and canine (PC1 and PC2) prostate cancer cell lines.
| Cell line | Origin | PSA expression |
AR expression |
Mutational Status | Cell line derived |
|---|---|---|---|---|---|
| LNCaP | Human | Positive | Positive |
AR p.Thr878Ala (c.2632A>G); MEN1 p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A) PIK3R1 p.Arg639Ter (c.1915C>T) PTEN p.Lys6Argfs*4 (c.17_18delAA) |
lymph node metastasis |
| PC3 | Human | Negative | Negative | TP53 p.Lys139Argfs*31 (c.414delC) (413delC) | bone metastasis |
| PC1 | Canine | * | Negative | Na | non-metastatic carcinoma |
| PC2 | Canine | * | Negative | Na | metastatic carcinoma |
PSA: Prostate specific antigen; AR: Androgen receptor; na: Not available; dogs have no PSA gene.