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. 2024 Apr 2;14:7709. doi: 10.1038/s41598-024-57645-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Baseline fold changes in systemic soluble mediators in adults following 17DD-YF 1/5 fractional dose primary vaccination. Systemic soluble mediators were measured in plasma samples from all volunteers before [NV_(D0), n = 15] and 30–45 days after [PV_(D30–45), n = 15] 17DD-YF 1/5 fractional dose primary vaccination. Measurements were carried out by xMAP technology as described in “Methods” section. The baseline fold change in the levels of each soluble mediator was calculated for individual samples as the ratio between values, expressed in pg/mL or MFI (#), observed at PV_(D30–45) divided by those detected at NV_(D0). The baseline fold change values were highlighted by shades of green to represent decreased (≥ 0.5 and ≤ 0.80/ or > 0.80 and < 1/) and red to underscore increased values (> 1 and ≤ 1.50/ or > 1.50/) baseline fold change values. Unaltered levels (baseline fold change = 1.0) are represented by gray color () and missing data by white color (▭). (A) A panoramic dashboard was constructed to calculate the median value for each soluble mediator further organized in ascendant manner. (B) Scattering of individual values over bar charts underscore the decreased (shades of green), unaltered (gray) and increased (shades of red) median baseline fold change values. Dashed lines indicate the cut-offs employed to classify values according to distinct color shades (0.8, 1.0 and 1.5).

Inline graphic — Baseline fold changes in systemic soluble mediators in adults following 17DD-YF 1/5 fractional dose primary vaccination. Systemic soluble mediators were measured in plasma samples from all volunteers before [NV_(D0), n = 15] and 30–45 days after [PV_(D30–45), n = 15] 17DD-YF 1/5 fractional dose primary vaccination. Measurements were carried out by xMAP technology as described in “Methods” section. The baseline fold change in the levels of each soluble mediator was calculated for individual samples as the ratio between values, expressed in pg/mL or MFI (#), observed at PV_(D30–45) divided by those detected at NV_(D0). The baseline fold change values were highlighted by shades of green to represent decreased (≥ 0.5 and ≤ 0.80/ or > 0.80 and < 1/) and red to underscore increased values (> 1 and ≤ 1.50/ or > 1.50/) baseline fold change values. Unaltered levels (baseline fold change = 1.0) are represented by gray color () and missing data by white color (▭). (A) A panoramic dashboard was constructed to calculate the median value for each soluble mediator further organized in ascendant manner. (B) Scattering of individual values over bar charts underscore the decreased (shades of green), unaltered (gray) and increased (shades of red) median baseline fold change values. Dashed lines indicate the cut-offs employed to classify values according to distinct color shades (0.8, 1.0 and 1.5).