Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 8;20(4):374–402. doi: 10.1038/s44320-024-00024-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

PMC Copyright notice

(A) Metaplots show H3K27ac read aggregation in promoters (left) and enhancers (right), centered at the peak summits. Number (n) indicates significant H3K27ac signal gains or losses in livers of HFDm compared to CDm. The average signal is depicted (n = 3 mice per condition). (B) Genome browser view (mm10) illustrates genomic region around the Tead1 gene locus. Black boxes represent exons and UTRs. Arrows indicate gene transcription directionality. The scale bar shows genomic region length in kilobases (kb). Black arcs display promoter-capture Hi-C (CHi-C) 3D connections. Genomic regions are enriched for CTCF (black peaks) with CTCF motif orientations determined with FIMO (plus or minus symbols), ERα (black peaks), ERα input (black peaks), significant ERα peaks (black insets), H3K27ac (color-coded peaks) in CDm, HFDm and ER-agonist-treated HFDm, H3K4me3, and H3K4me1 (horizontal gray bar; dark: high, light: low). One replicate per condition is shown. The y axis of each track specifies normalized read density. Genomic location of enhancers (numbered from 1 to 4) paired with the Tead1 gene locus are highlighted (gray vertical boxes). The degree of genomic sequence conservation in vertebrates is shown (conserved: black, not conserved: white). Scatter plots correlate Tead1 gene expression (TPM, y axis) and its paired enhancers (H3K27ac signal, x axis) in the livers of male mice on different diets and ER-agonist treatments. All three biological replicates are shown. Enhancer coordinates (400 bp window around the enhancer summit), Pearson correlation coefficients (r) and significance (p) are indicated in each box.