Fig. 5. Immune dysfunction in obese hosts increases cancer risk.

After 12 weeks on normal chow (NC) or western diet (WD), A wild-type (WT) B6 (n = 100) and Rag2^−/− (n = 40) mice received a single subcutaneous injection of 3’-methylcholanthrene (MCA; 50 μg) and were monitored for sarcoma tumor development out to 120 days. B Tumor incidence was defined as the development of a palpable sarcoma with a diameter of 8 mm and was graphed for each cohort versus time and displayed in Kaplan–Meier curves. C The percent and number (inset) of tumor-bearing and tumor-free mice from each cohort at 120 days is shown, with exact P values indicated for the bracketed groups calculated by two-sided Chi-squared analysis. A Created using BioRender.com.