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. 2024 Apr 2;14:6797. doi: 10.1038/s41598-024-56837-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Statistical results of the hydrophilic metabolome data. (a) Volcano plot comparing CN and AD. A healthy control was set to the base of the fold change calculation. (b,c) Box plots of ST 24:1;O5 and ST 24:1;O4;G. (d) Volcano plot comparing pMCI and sMCI, with sMCI set as the base for fold change calculation. (e) Box plot of ergothioneine. False discovery rate (FDR) correction was used to adjust the P-values in (a–e). (f–i) Cox proportional hazard model using hydrophilic metabolite information (f: ergothioneine, g: palmitoleamide, h: oleamide, i: diacylglycerol (DG) 16:0_18:2). The x- and y-axes show the actual time (month) to diagnosis of dementia from MCI and the ratio (max = 1) showing the remaining MCI patients, respectively. HR, overall hazard ratio.