Table 3.
Results of Cox proportional model for metabolites and number of APOE4 alleles.
| Class | Rate of MCI patients (24 month) | Hazard ratio | P-value |
|---|---|---|---|
| APOE4 = 0, ergothioneine > − 0.360 | 87% | – | – |
| APOE4 = 0, ergothioneine ≤ − 0.360 | 85% | 1.1 | 0.77 |
| APOE4 ≥ 1, ergothioneine > − 0.360 | 73% | 2.4 | 0.0038 |
| APOE4 ≥ 1, ergothioneine ≤ − 0.360 | 52% | 4.7 | 3.7e−08 |
| APOE4 = 0, GM3 d18:1/20:0 ≤ − 0.085 | 83% | – | – |
| APOE4 = 0, GM3 d18:1/20:0 > − 0.085 | 69% | 1.9 | 0.001 |
| APOE4 ≥ 1, GM3 d18:1/20:0 ≤ − 0.085 | 62% | 2.7 | 7.5e-07 |
| APOE4 ≥ 1, GM3 d18:1/20:0 > − 0.085 | 43% | 4.6 | 2.3e-16 |
The rate of MCI patients indicates the rate of those who retained MCI status at 24 months from baseline. A hyphen (–) indicates control. P-values and hazard ratios were calculated compared to a control group. P-values were calculated using the Wald test.