Table 1.
Summary of natural AAV receptors and tissue specificity in humans
| AAV serotype | Origin | Receptor for cellular attachment | Receptors for post-attachment | Tissue tropism in human | |
|---|---|---|---|---|---|
| Primary receptors | Co-receptors | ||||
| AAV1 | NHP | N-linked sialic acid | Unknown | AAVR, GPR108 | Skeletal muscle, CNS, airway, retina, pancreas |
| AAV2 | Human | HSPG | FGFR1, HGFR, LamR, CD9, Tetraspanin | AAVR, GPR108 | Retina, CNS |
| AAV3 | Human | HSPG | FGFR1, HGFR, LamR | AAVR, GPR108 | Liver |
| AAV4 | NHP | O-linked sialic acid | Unknown | GPR108 | Lung |
| AAV5 | Human | N-linked sialic acid | PDGFR | AAVR | Retina, CNS, kidney, pancreas, liver |
| AAV6 | Human | N-linked sialic acid | EGFR | AAVR, GPR108 | Airway, CNS |
| AAV7 | NHP | Unknown | Unknown | Unknown | Liver |
| AAV8 | NHP | Unknown | LamR | AAVR, GPR108 | Liver, CNS, retina |
| AAV9 | Human | Galactose | LamR | AAVR, GPR108 | Heart, CNS |
| rh8 | NHP | Unknown | Unknown | Unknown | CNS |
| rh10 | NHP | Unknown | Unknown | Unknown | CNS, skeletal muscle |
| rh74 | NHP | Unknown | Unknown | Unknown | Skeletal muscle |
CNS central nervous system, FGFR1 fibroblast growth factor receptor 1, HGFR hepatocyte growth factor receptor, PDGFR platelet-derived growth factor receptor, EGFR epidermal growth factor receptor, LamR 37/67 kDa laminin receptor, AAVR adeno-associated virus receptor, GPR108 G protein-coupled receptor 108