TABLE 1.

Ongoing clinical trials with HER-2 targeting ADCs.

ADC	Trial	Phase	Number of patients	Drugs involved	Condition or disease	Status
Trastuzumab emtansine (T-DM1)	NCT02999672	phase II	20	Trastuzumab Emtansine	Bladder Cancer, Pancreas Cancer, Cholangiocellular Carcinoma	Completed
	NCT02675829	phase II	140	Ado-Trastuzumab Emtansine	Solid Tumor Cancers, Lung Cancer, Bladder Cancer, Urinary Tract Cancers	Recruiting
	NCT04632992	phase II	252	Entrectinib, Inavolisib, Alectinib, Ipatasertib, Atezolizumab, Trastuzumab, Emtansine, Pertuzumab + Trastuzumab + Hyaluronidase-zzxf, Tucatinib, Investigator’s Choice of Chemotherapy, Paclitaxel, Tiragolumab, Pralsetinib	Advanced Unresectable or Metastatic Solid Malignancy	Active, not recruiting
Trastuzumab deruxtecan (T-DXd)	NCT04644068	phase II	604	AZD5305, Paclitaxel, Carboplatin, T-Dxd, Dato-DXd, Camizestrant	Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer, Non-small Cell Lung Cancer, Small Cell, Lung Cancer, Colorectal Cancer, Bladder Cancer, Gastric Cancer, Biliary Cancer, Cervical Cancer, Endometrial Cancer	Recruiting
	NCT04482309	phase II	468	Trastuzumab deruxtecan	Bladder Cancer, Biliary Tract Cancer, Cervical Cancer, Endometrial Cancer, Ovarian Cancer, Pancreatic Cancer, Rare Tumors	Active, not recruiting
Disitamab vedotin (RC48)	NCT04879329	phase II	332	disitamab vedotin, pembrolizumab	Urothelial Carcinoma	Recruiting
	NCT05495724	phase II	176	Disitamab Vedotin + Tislelizumab	Her2 Overexpressing High-Risk Non-Muscle Invasive Bladder Urothelial Carcinoma	Recruiting
	NCT05837806	phase II	27	Tislelizumab + Disitamab vedotin	Upper Tract Urothelial Carcinoma	Recruiting
	NCT03809013	phase II	60	Disitamab vedotin	HER2 Overexpressing Locally Advanced or Metastatic Urothelial Cancer	Active, not recruiting
	NCT04073602	phase II	19	Disitamab vedotin	Locally Advanced or Metastatic HER2-negative Urothelial Cancer	Active, not recruiting
	NCT05488353	phase IV	48	Disitamab Vedotin + Penpulimab	Cisplatin Intolerant CT2-T4anxm0 Bladder Urothelial Carcinoma	Not yet recruiting