Figure 2.

APOE3Ch decreases pTau S396. Cerebral organoids were formed and stained for nuclei and pTau S396 and imaged at 63X. Representative images from patient ω. (A) and patient α (C) depicted, scale bars = 50 μm. pTau S396 signal intensity was measured, and isogenic controls for each individual patient were averaged together (B,D). Quantification was performed on three to four organoids per line with n = 31–159 measurements for patient α and n = 25–47 measurements for patient ω.