Table 1.

The correlation between A. muciniphila abundance levels and metabolic diseases.

Research subjects	Condition	Study grouping	Sample collection and testing methods	Variation in abundance of A. muciniphila	Ref.
Human	Obesity	30 volunteers from Colombians	Feces 16S rRNA sequencing	↓: decreased in volunteers with high BMI.	(59)
Mice	Diet-induced obesity	N = 6, chow diet N = 6, high-fat diet (HFD)	Cecal sample qPCR	↓: progressively declined in HFD group	(60)
Mice	HFD induced obesity	N = 7, chow die N = 7, HFD	Feces qPCR	↓: lower in HFD group.	(61)
Mice	HFD induced obesity	N = 6, normal diet N = 6, HFD	Feces 16S rRNA sequencing and qPCR	↓: lower in HFD group.	(62)
Human	Obesity	N = 50, normal weight N = 50, obesity	Feces qPCR	↓: significantly decrease in obese group	(63)
Mice	Diet-induced obesity	N = 12, low fat diet N = 12, HFD	Cecal sample 16S rRNA sequencing	↓: lower in HFD fed mice.	(64)
Human	Obesity and T2DM	N = 151, T2DM patients N = 50, healthy controls	Feces 16S rRNA sequencing	↓: decreased in T2DM patients	(65)
Human	Lean T2DM	N = 22, control N = 52, abdominal obesity N = 22, T2DM N= 56, T2DM and abdominal obesity	Feces Metagenomic	↓: decreased in lean T2DM patients	(66)
Mice	NASH	N = 6, control N = 6, methionine- choline-deficient (MCD) diet	Feces 16S rRNA sequencing	↓: decreased in MCD group	(67)
Mice	NAFLD	N = 6, normal chow N = 6, HFD N = 6, chow + betaine N=6, HFD + betaine	Feces 16S rRNA sequencing	↓: decreased in the lean HFD group	(68)

"↓" represents a decrease in the abundance of A. muciniphila.