TABLE 1.
Primary and secondary arrhythmias due to chemotherapy-related cardiotoxicity.
| Classification of CDIA | Classification of chemotherapeutic agents | Cardiotoxicity endpoint | References |
|---|---|---|---|
| Primary | Anthracyclines | QTc interval prolongation | Buza et al. (2017) |
| Thalidomide | —— | Rajkumar et al. (2003) | |
| Alectinib, Ceritinib, Crizotinib, Ibrutinib, Ponatinib | QTc interval prolongation | Buza et al. (2017) | |
| Cisplatin | QTc interval prolongation | Thix et al. (2009) | |
| Secondary | Anthracyclines | Cardiomyopathy | Buza et al. (2017) |
| 5-Fluorouracil | Myocardial ischemia | Khan, et al. (2012) | |
| bortezomib, carfilzomib | Heart failure | Buza et al. (2017) | |
| Dasatinib | Cardiomyopathy | Buza et al. (2017) | |
| sunitinib | Heart failure | Buza et al. (2017) | |
| Trastuzumab | Left ventricular systolic dysfunction | Piotrowski et al. (2012) | |
| Pembrolizumab, nivolumab | Myocarditis | Heinzerling et al. (2016), Behling et al. (2017) |
——: Not mentioned.