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. 2024 Mar 20;14:1357790. doi: 10.3389/fonc.2024.1357790

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Copyright © 2024 Peng, Deng, Jiang and Timmerman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) 19 HNSCC patients, primary tumors and lymph nodes (from ref 45). (B) 22 NSCLC patients, non-recurrent group (13 patients) and recurrent group (9 patients) (from ref 46). (C) Relationship between FMISO SUV and pO₂. The solid line represents the selected baseline reference (pO₂ = 10 mmHg). The dotted line represents the hypoxic state, corresponding to a higher SUV and a lower OER. (D) Relationship between OER and pO_2. (E) The TCP dose-response curve (a sigmoid function) changes along with the hypoxic condition and associated radio-sensitivity.