Table 2.
GSEA of pyroptosis-related DEGs between left- and right-sided CRC.
| KEGG pathways | Enrichment Score | NES | adjust p |
|---|---|---|---|
| KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION | 0.661179208 | 2.266199478 | 0.00203666 |
| KEGG_AUTOIMMUNE_THYROID_DISEASE | 0.561785796 | 1.773646458 | 0.002057613 |
| KEGG_ALLOGRAFT_REJECTION | 0.673029598 | 1.977277154 | 0.002066116 |
| KEGG_TYPE_I_DIABETES_MELLITUS | 0.626924973 | 1.900427653 | 0.002079002 |
| KEGG_GRAFT_VERSUS_HOST_DISEASE | 0.788442015 | 2.338560295 | 0.002083333 |
| KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS | 0.576379881 | 1.833604484 | 0.002087683 |
| KEGG_HEMATOPOIETIC_CELL_LINEAGE | 0.508706798 | 1.747633752 | 0.002114165 |
| KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION | 0.740390085 | 2.282364097 | 0.002114165 |
| KEGG_LEISHMANIA_INFECTION | 0.57575029 | 1.908415615 | 0.002132196 |
| KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY | 0.574450536 | 2.089643678 | 0.002188184 |
| KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION | 0.420342428 | 1.663437574 | 0.002336449 |
| KEGG_ASTHMA | 0.651036339 | 1.78879836 | 0.004166667 |
| KEGG_WNT_SIGNALING_PATHWAY | −0.402171014 | −1.436822935 | 0.007285974 |
| KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | 0.42453241 | 1.481282957 | 0.008888889 |
| KEGG_BASAL_CELL_CARCINOMA | −0.514589951 | −1.594710126 | 0.017175573 |
| KEGG_COMPLEMENT_AND_COAGULATION_CASCADES | −0.468181315 | −1.509505877 | 0.018761726 |
| KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY | 0.408955279 | 1.448361504 | 0.019522777 |
| KEGG_VIRAL_MYOCARDITIS | 0.441439242 | 1.460864752 | 0.027659574 |
| KEGG_JAK_STAT_SIGNALING_PATHWAY | 0.360607959 | 1.341985658 | 0.028953229 |
| KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM | −0.550299301 | −1.515341327 | 0.031311155 |
| KEGG_ASCORBATE_AND_ALDARATE_METABOLISM | 0.576262606 | 1.560865858 | 0.032653061 |
| KEGG_STEROID_BIOSYNTHESIS | −0.618751558 | −1.507694503 | 0.04109589 |
| KEGG_PRIMARY_IMMUNODEFICIENCY | 0.522016959 | 1.533620823 | 0.041322314 |
| KEGG_DRUG_METABOLISM_CYTOCHROME_P450 | 0.411747929 | 1.373510758 | 0.042283298 |
| KEGG_CHEMOKINE_SIGNALING_PATHWAY | 0.336459724 | 1.27353271 | 0.043478261 |
| KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | −0.330605032 | −1.271689665 | 0.045936396 |
GSEA: gene set enrichment analysis; DEG: differentially expressed genes; CRC: colorectal cancer; KEGG: Kyoto Encyclopedia of Genes and Genomes; NES: normalized enrichment score.
Statistical p value was adjusted by Benjamini-Hochberg method.