TABLE 1.
Characteristics of the ARIC‐PET analytic sample at visit 2, stratified by levels of social relationships (n = 310).
| Characteristics | Strong social relationships (n = 188) | Average social relationships (n = 86) | Poor social relationships (n = 36) | p value |
|---|---|---|---|---|
| Age, y, mean (SD) | 54.8 (5.2) | 55.7 (5.4) | 54.9 (4.3) | 0.40 |
| Race, N (%) | 0.94 | |||
| Black (n = 125) | 75 (39.9) | 36 (41.9) | 14 (38.9) | |
| White (n = 185) | 113 (60.1) | 50 (58.1) | 22 (61.1) | |
| Sex, N (%) | 0.002 | |||
| Female (n = 175) | 119 (63.3) | 44 (51.2) | 12 (33.3) | |
| Male (n = 135) | 69 (36.7) | 42 (48.8) | 24 (66.7) | |
| Field Center, N (%) | 0.68 | |||
| Forsyth | 47 (25.0) | 16 (18.6) | 6 (16.7) | |
| Jackson | 71 (37.8) | 34 (39.5) | 14 (38.9) | |
| Minneapolis | — | — | — | |
| Washington | 70 (37.2) | 36 (41.9) | 16 (44.4) | |
| APOE ε4 status, N (%) (n = 305) | 0.83 | |||
| Non‐carrier | 127 (67.6) | 58 (67.4) | 27 (75.0) | |
| Carrier | 58 (30.9) | 27 (31.4) | 8 (22.2) | |
| Education level, N (%) | 0.001 | |||
| Less than high school | 23 (12.2) | 21 (24.4) | 2 (5.6) | |
| High school or equivalent | 73 (38.8) | 44 (51.2) | 18 (50.0) | |
| More than high school | 92 (48.9) | 21 (24.4) | 16 (44.4) | |
| Not married, N (%) | 28 (14.9) | 16 (18.6) | 12 (33.3) | 0.03 |
|
Elevated florbetapir global SUVR (>1.2) at visit 5, N (%) |
101 (53.7) | 36 (41.9) | 13 (36.1) | 0.06 |
| Cognitive status of MCI at visit 5, N (%) | 42 (22.3) | 27 (31.4) | 13 (36.1) | 0.11 |
| Physically inactive at visit 1 (0 min/wk), N (%) | 71 (37.8) | 36 (41.9) | 13 (36.1) | 0.77 |
| Depressive/fatigue symptoms, N (%) | 42 (22.3) | 34 (39.5) | 15 (41.7) | 0.003 |
| Hypertension, N (%) | 50 (26.6) | 26 (30.2) | 15 (41.7) | 0.19 |
| Diabetes, N (%) | 14 (7.5) | 14 (16.3) | 4 (11.1) | 0.08 |
| Body mass index (≥30 kg/m2), N (%) | 50 (26.6) | 25 (29.1) | 14 (38.9) | 0.33 |
| Total cholesterol (≥200 mg/dL), N (%) | 93 (49.5) | 39 (45.4) | 14 (38.9) | 0.47 |
| Current smoker, N (%) | 28 (14.9) | 16 (18.6) | 5 (13.9) | 0.70 |
| Current drinker, N (%) | 103 (54.8) | 44 (51.2) | 17 (47.2) | 0.66 |
| Developed dementia by visit 7, N (%) | 25 (13.3) | 16 (18.6) | 7 (19.4) | 0.42 |
| Died prior to visit 7, N (%) | 13 (6.9) | 7 (8.1) | 3 (8.3) | 0.92 |
Note: Baseline differences assessed with analysis of variance (ANOVA) for continuous variables and χ2 tests for categorical values. No PET scans were conducted at Minneapolis ARIC Field Center.
Abbreviations: APOE, apolipoprotein E; MCI, mild cognitive impairment; SUVR, standardized uptake value ratio.