TABLE 2.
Adjusted hazard ratios for association of mid‐life social relationships and elevated florbetapir global SUVR with dementia risk (n = 305).
| Variables | Model 1 HR (95% CI) | Model 2 HR (95% CI) | Model 3 HR (95% CI) |
|---|---|---|---|
| Strong social relationships | 0.32 (0.12–0.86) * | 0.35 (0.13–0.94) * | 0.45 (0.16–1.23) |
| Average social relationships | 0.29 (0.10–0.80) * | 0.27 (0.10–0.78) * | 0.28 (0.10–0.80) * |
| Poor social relationships | Reference | Reference | Reference |
| Elevated florbetapir global SUVR >1.2 | 4.04 (1.93–8.46) ** | 4.14 (1.93–8.87) ** | 3.25 (1.47–7.17) ** |
| Age (per 1 year) | 1.15 (1.07–1.23) ** | 1.15 (1.07–1.23) ** | 1.16 (1.08–1.25) ** |
| Race (Black) | 1.71 (0.90–3.22) | 1.97 (1.01–3.82) * | 1.94 (0.99–3.80) |
| Sex (Female) | 0.55 (0.29–1.03) | 0.58 (0.28–1.18) | 0.56 (0.27–1.16) |
| APOE ε4 carrier | 2.27 (1.25–4.14) ** | 2.06 (1.11–3.81) * | 2.13 (1.15–3.94) * |
| Education | |||
| Less than high school | 2.80 (1.31–5.96) ** | 2.99 (1.27–7.01) * | 3.61 (1.51–8.65) ** |
| High school or equivalent | 0.79 (0.38–1.65) | 0.91 (0.40–2.04) | 1.06 (0.47–2.38) |
| More than high school | Reference | Reference | Reference |
| Not married | 1.17 (0.53–2.59) | 0.86 (0.35–2.10) | 1.02 (0.41–2.55) |
| Depressive/fatigue symptoms | — | 0.91 (0.43–1.94) | 0.98 (0.45–2.13) |
| Hypertension | — | 1.02 (0.54–1.95) | 1.20 (0.62–2.32) |
| Diabetes | — | 2.77 (1.20–6.37) * | 2.04 (0.84–4.96) |
| Body mass index (≥30 kg/m2) | — | 1.73 (0.88–3.40) | 1.88 (0.96–3.71) |
| Total cholesterol (≥200 mg/dL) | — | 0.52 (0.27–0.98) * | 0.54 (0.29–1.00) |
| Current smoker | — | 1.22 (0.48–3.10) | 1.50 (0.58–3.89) |
| Current drinker | — | 0.54 (0.28–1.05) | 0.68 (0.34–1.35) |
| Physical inactivity at visit | — | 0.75 (0.39–1.43) | 0.76 (0.40–1.45) |
| Having MCI at visit 5 | — | — | 2.47 (1.22–5.00) * |
Note: Model 1 adjusted for age, race, sex, APOE ε4, education, and marital status. Model 2 adjusted for model 1 covariates in addition to depressive/fatigue symptoms, vascular risk factors, and physical inactivity. Model 3 adjusted for model 2 covariates in addition to having MCI at visit 5.
Abbreviations: APOE, apolipoprotein E; CI, confidence interval; HR, hazard ratio; MCI, mild cognitive impairment; SUVR, standardized uptake value ratio.
*
p ≤ 0.05.
**
p ≤ 0.01.