Figure 4.

(I) Extraction of raw, ground propolis using hydro-alcoholic solvents; (II) Development of Propolis-Based NLCs; (III) Evaluation of the efficacy of Propolis-EXTR and Propolis-NLCs in promoting wound healing in contrast to a control group administered carbopol alone. (A) A schematic depicting the experimental design for a rabbit study including a full-thickness skin damage and the treatment groups. (B) The sizes of wounds are shown in representative photographs. (C) Ratio of wound healing in the control, Propolis-EXTR, and Propolis-NLCs groups following injury induction (0 day), 7, 14, and 21 days later for qualitative analysis. Reproduced with the permission from ref. 76. Fig. 1, Fig. 2 and Fig. 6 (Springer).