Figure 7.

(I) Enhanced endosomal escape capability and prompted parent CPT drug release in the cytoplasm are depicted schematically in the pH- and reduction-responsive prodrug micelles; (II) (A) Examining the in vivo biodistribution of DiR iodide-loaded PCI-NPs using intravenous contrast imaging in BALB/c mice carrying the H22 tumour following intravenous injection. (B) After 24 hours of intravenous injection of PCI-NPs, fluorescent imaging of the tumour and key organs was performed on killed mice. (C) Assessment of tumour and primary organs following intravenous PCI-NP injection using semi-quantitative methods. Reproduced with the permission ref. 101 Scheme 2, and Fig. 5 (ACS Publications).