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. 2024 Mar 11;15(9):2561–2572. doi: 10.7150/jca.92386

Figure 3.

Figure 3

USP15 modulates HMGB1 stability in a DUB(Deubiquitinases)-dependent manner. A: The expression levels of HMGB1 protein in B-CPAP cells and KTC-1 cells knocked down USP15. The expression levels of HMGB1 protein in USP15-deficient B-CPAP cells (B) and KTC-1 cells (C) were treated with CHX (cycloheximide) at different times. D: HMGB1 mRNA expression levels in PTC cells with overexpression of USP15 or with low expression of USP15. E: The expression levels of HMGB1 protein in USP15-deficient PTC cells treated with the peptide-aldehyde proteasome inhibitor MG132 (carbobenzoxyl-L-leucyl-L-leucyl-L-leucine). F: The expression levels of HMGB1 protein in USP15 C298A transfected PTC cells treated with MG132. ***P<0.001.