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USP15 deubiquitylates HMGB1. A: Immunoblotting to detect the ubiquitination of HMGB1 protein in PTC cells transfected with USP15 shRNA. Immunoblotting to detect the ubiquitination of HMGB1 protein in HEK-293T cells (B) and B-CPAP cells (C) transfected with USP15 and USP15 C298A mutant. Immunoblotting to detect the His-tag in USP 15 overexpression HEK-293T cells (D) and B-CPAP cells (E) transfected with His-Ub, His-K48 Ub, and His-K48R Ub mutant.
