Table 1.

miRNAs and their targets in aerobic glycolysis in three major gynecological tumors

Glycolytic protein	MiRNAs	Role	Expression	Mechanism	Type of cancer		References
HK2	miR-145, miR-148a, miR-497	CSCs, chemotherapy resistance	down	/		CC	18
	miR-9-5p	Tumor suppressor	down	AKT/mTOR, p53		CC	17
	miR-143-3p	-	down	Myc		CC	70
	circCDKN2B-AS1	Tumor suppressor	up	IMP3		CC	71
LDHA	miR-34a	chemotherapy sensitivity	down	lncRNA NEAT1		CC	23
PDK1	miR-126-3p	Tumor suppressor	down	Bcl-xL, Bax, caspase 3/7		CC	28
	miR-155-5p	autophagy	down	LC3, P62		CC	29
PDK4	miR‐103a‐3p	Tumor promoter	down	ncRNA LINC00662		CC	30
	miR-16-5p	chemotherapy resistance	down	/		CC	31
PKM2	miR-let-7a	Tumor suppressor	down	/		CC	72
IDH2	miR-124-5p	Tumor promoter	down	HIF-1α		CC	44
HK2	miR-455, miR-181a	EMT	down	DLEU2, EZH2		EC	55
HK2	miR-603	Tumor suppressor	down	20(S)-Rg3, DNMT3A		OC	73
	miR‐145	/	down	DNMT3A		OC	74
	miR-1244	Tumor promoter	down	lncRNA LINC00504		OC	75
LDHA	miR-383	Tumor suppressor	down	/		OC	76
PDK4	miR-107	Tumor promoter	down	lncRNA AFAP1-AS1		OC	77
PKM2	miR-324-5p	Tumor suppressor	down	20(S)-Rg3, H19		OC	78
	miR-1244	Tumor promoter	down	lncRNA LINC00504		OC	75
PDK1	miR-1244	Tumor promoter	down	lncRNA LINC00504		OC	75
CDH1	miR-106a	Tumor promoter	down	circ-ITCH		OC	79
circ-PGAM1	miR-542-3p	Tumor promoter	down	CDC5L, PEAK1		OC	80
GADPH	miR-125b	Tumor promoter	down	STAT3		OC	81
GLUT-1	miR-1204	Tumor promoter	up	/		OC	82