Table 2. IRs per 10 000 Person-Years and aHRs of Depression, Anxiety, or Stress-Related Disorders .
| Biomarkera | Depression, anxiety, or stress-related disorders | Depression | Anxiety | Stress-related disorders | ||||
|---|---|---|---|---|---|---|---|---|
| No. of events (IR) | aHR (95% CI) | No. of events (IR) | aHR (95% CI) | No. of events (IR) | aHR (95% CI) | No. of events (IR) | aHR (95% CI) | |
| High glucose (≥6.11 mmol/L) | ||||||||
| Yes | 622 (41.5) | 1.30 (1.20-1.41) | 416 (27.4) | 1.36 (1.23-1.50) | 261 (17.0) | 1.22 (1.08-1.38) | 130 (8.5) | 1.25 (1.04-1.49) |
| No | 13 455 (36.2) | 1.0 [Reference] | 7949 (21.1) | 1.0 [Reference] | 6338 (16.7) | 1.0 [Reference] | 4164 (10.9) | 1.0 [Reference] |
| High total cholesterol (≥5.00 mmol/L) | ||||||||
| Yes | 8987 (35.1) | 1.01 (0.98-1.05) | 5532 (21.3) | 1.00 (0.95-1.05) | 4154 (15.9) | 1.04 (0.99-1.10) | 2248 (8.6) | 1.00 (0.94-1.06) |
| No | 5575 (38.4) | 1.0 [Reference] | 3151 (21.4) | 1.0 [Reference] | 2662 (17.9) | 1.0 [Reference] | 2157 (14.5) | 1.0 [Reference] |
| High triglycerides (≥1.71 mmol/L) | ||||||||
| Yes | 2497 (36.2) | 1.15 (1.10-1.20) | 1608 (23.0) | 1.18 (1.12-1.25) | 1132 (16.1) | 1.16 (1.09-1.24) | 645 (9.15) | 1.21 (1.11-1.32) |
| No | 11 982 (36.3) | 1.0 [Reference] | 7030 (21.0) | 1.0 [Reference] | 5644 (16.7) | 1.0 [Reference] | 3735 (11.0) | 1.0 [Reference] |
| High LDL-C (≥3.00 mmol/L) | ||||||||
| Yes | 3973 (33.8) | 1.01 (0.95-1.06) | 2459 (20.7) | 0.98 (0.91-1.06) | 1810 (15.1) | 0.99 (0.91-1.07) | 945 (7.9) | 0.98 (0.88-1.08) |
| No | 2234 (37.0) | 1.0 [Reference] | 1279 (20.9) | Ref | 1087 (17.7) | Ref | 834 (13.5) | Ref |
| High HDL-C (≥1.03 mmol/L) | ||||||||
| Yes | 6019 (34.8) | 0.88 (0.80-0.97) | 3583 (20.4) | 0.91 (0.80-1.03) | 2820 (16.0) | 0.78 (0.68-0.90) | 1762 (10.0) | 0.87 (0.72-1.05) |
| No | 448 (33.2) | 1.0 [Reference] | 271 (19.8) | 1.0 [Reference] | 228 (16.6) | 1.0 [Reference] | 122 (8.8) | 1.0 [Reference] |
| High LDL-C/HDL-C ratio (≥3.50) | ||||||||
| Yes | 701 (31.6) | 1.06 (0.97-1.14) | 444 (19.8) | 1.04 (0.94-1.15) | 325 (14.4) | 1.10 (0.98-1.24) | 139 (6.2) | 0.97 (0.81-1.16) |
| No | 5 252 (35.3) | 1.0 [Reference] | 3114 (20.7) | 1.0 [Reference] | 2465 (16.3) | 1.0 [Reference] | 1591 (10.4) | 1.0 [Reference] |
| High ApoA-I (≥1.00 mmol/L in men and 1.10 mmol/L in women) | ||||||||
| Yes | 5269 (34.3) | 0.92 (0.78-1.10) | 3155 (20.3) | 0.83 (0.67-1.03) | 2502 (16.0) | 1.04 (0.80-1.35) | 1499 (9.6) | 0.88 (0.66-1.19) |
| No | 135 (37.4) | 1.0 [Reference] | 88 (24.1) | 1.0 [Reference] | 58 (15.7) | 1.0 [Reference] | 45 (12.2) | 1.0 [Reference] |
| High ApoB (≥0.90 mmol/L) | ||||||||
| Yes | 3574 (32.9) | 0.95 (0.88-1.02) | 2159 (19.7) | 0.94 (0.85-1.04) | 1690 (15.3) | 1.02 (0.91-1.13) | 901 (8.1) | 0.86 (0.76-0.98) |
| No | 1001 (37.6) | 1.0 [Reference] | 548 (20.2) | 1.0 [Reference] | 463 (17.0) | 1.0 [Reference] | 405 (14.8) | 1.0 [Reference] |
| High ApoB/ApoA-I ratio (≥0.90 in men and 0.80 in women) | ||||||||
| Yes | 1599 (32.9) | 1.06 (0.99-1.13) | 984 (20.0) | 1.04 (0.96-1.14) | 765 (15.5) | 1.12 (1.01-1.23) | 355 (7.2) | 1.00 (0.87-1.14) |
| No | 2207 (33.2) | 1.0 [Reference] | 1274 (18.9) | 1.0 [Reference] | 1043 (15.4) | 1.0 [Reference] | 715 (10.5) | 1.0 [Reference] |
Abbreviations: aHR, adjusted hazard ratio; ApoA-I, apolipoprotein A-I; ApoB, apolipoprotein B; HDL-C, high-density lipoprotein cholesterol; IR, incidence rate; LDL-C, low-density lipoprotein cholesterol.
SI conversion factors: To convert glucose to milligrams per deciliter, divide by 0.0555; to convert total cholesterol, HDL-C, and LDL-C to milligrams per deciliter, divide by 0.0259; to convert triglycerides to milligrams per deciliter, divide by 0.0113; to convert ApoA-I and ApoB to milligrams per deciliter, multiply by 0.01.
a
Adjusted for age at first blood sampling, sex, fasting status at first blood sampling, country of birth, and socioeconomic status.