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. 2024 Apr 2;7(4):e244525. doi: 10.1001/jamanetworkopen.2024.4525

Table 3. IRs per 10 000 Person-Years and aHRs of Depression, Anxiety, or Stress-Related Disorders for 1-SD Increase in Carbohydrate, Lipid, and Apolipoprotein Biomarker Levels .

Biomarkera Depression, anxiety, or stress-related disorders Depression Anxiety Stress-related disorders
No. of events (IR) aHR (95% CI) No. of events (IR) aHR (95% CI) No. of events (IR) aHR (95% CI) No. of events (IR) aHR (95% CI)
Glucose 14 077 (36.4) 1.07 (1.05-1.09) 8365 (21.4) 1.08 (1.05-1.10) 6599 (16.8) 1.07 (1.04-1.10) 4294 (10.9) 1.07 (1.03-1.11)
TC 14 562 (36.5) 1.02 (1.00-1.04) 8683 (21.4) 1.02 (1.00-1.05) 6816 (16.7) 1.04 (1.01-1.07) 4405 (10.8) 1.00 (0.96-1.03)
TG 14 479 (36.3) 1.07 (1.05-1.09) 8638 (21.4) 1.08 (1.06-1.10) 6776 (16.7) 1.08 (1.06-1.10) 4380 (10.7) 1.07 (1.04-1.11)
LDL-C 6207 (34.9) 1.01 (0.98-1.04) 3738 (20.8) 1.00 (0.96-1.03) 2897 (16.0) 1.03 (0.99-1.08) 1779 (9.8) 0.99 (0.94-1.06)
HDL-C 6467 (34.7) 0.94 (0.92-0.97) 3854 (20.4) 0.95 (0.92-0.99) 3048 (16.1) 0.92 (0.89-0.96) 1884 (9.9) 0.95 (0.90-1.00)
LDL-C/HDL-C ratio 5953 (34.9) 1.03 (1.00-1.07) 3558 (20.6) 1.01 (0.98-1.06) 2790 (16.1) 1.06 (1.01-1.11) 1730 (9.9) 1.04 (0.98-1.10)
ApoA-I 5404 (34.4) 0.97 (0.94-1.00) 3243 (20.4) 0.98 (0.94-1.02) 2560 (16.0) 0.97 (0.93-1.02) 1544 (9.6) 0.97 (0.91-1.03)
ApoB 4575 (33.9) 0.98 (0.94-1.01) 2707 (19.8) 0.98 (0.94-1.03) 2153 (15.7) 1.00 (0.95-1.06) 1306 (9.5) 0.92 (0.85-0.99)
ApoB/ApoA-I ratio 3806 (33.1) 1.01 (0.97-1.05) 2258 (19.4) 1.00 (0.96-1.06) 1808 (15.5) 1.03 (0.97-1.09) 1070 (9.1) 0.98 (0.91-1.06)

Abbreviations: ApoA-I, apolipoprotein A-I; ApoB, apolipoprotein B; HDL-C, high-density lipoprotein cholesterol; IR, incidence rate; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglycerides.

a

Adjusted for age at first blood sampling, sex, fasting status, country of birth, and socioeconomic status.