Figure 2. Clinical Outcomes According to TIL Thresholds in the Overall Study Population and According to Stage.

^aIndicates sample sizes after multilevel multiple imputation for missing variables, as described in Methods.

Right panel illustrates point estimates for each survival end point in all patients, according to stage and tumor-infiltrating lymphocyte (TIL) level. Area of the circles is proportional to the sample size for each TIL subgroup. iDFS indicates invasive disease-free survival; RFS, recurrence-free survival; and DRFS, survival free of distant recurrence.